Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664915 | 0.89 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL8809138 | 0.84 | ADORA1 (0.64) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL5798902 | 0.84 | ADORA1 (0.55) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL5798621 | 0.84 | ADORA1 (0.55) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL5795745 | 0.84 | ADORA1 (0.55) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7658127 | 0.81 | ADORA1 (0.53) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7039587 | 0.81 | ADORA1 (0.57) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7299931 | 0.81 | ADORA1 (0.57) | ADORA1IGF1RMAPK1MAPK14MAPK3 | |
| SCHEMBL7304113 | 0.80 | ADORA1 (0.68) | ADORA1IGF1RMAPK1PDE3A | |
| SCHEMBL7295203 | 0.79 | ADORA1 (0.73) | ADORA1IGF1RMAPK1MAPK14MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355640-B1 | TREATMENT OF HYPERTENSION, UROGENITAL DISORDERS AND FORMED BY WITTIG REACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| US-5773530-A | USEFUL AS PSYCHOSTIMULANTS, ANTIHYPERTENSIVE AGENTS AND REMEDIES FOR RENAL FAILURE, DIURETICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |