Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.36 |
| ▸ | RAF1 | P04049 | 5/20 | 0.36 |
| ▸ | TEK | Q02763 | 4/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454834 | 0.88 | MAPT (0.39) | BRAFKDRRAF1TEKPTGES | |
| SCHEMBL5456410 | 0.80 | MAPT (0.39) | BRAFKDRRAF1TEKKDM4E | |
| SCHEMBL5796495 | 0.80 | PTGES (0.41) | BRAFKDRRAF1PTGES | |
| SCHEMBL5444078 | 0.74 | PTGES (0.41) | BRAFKDRRAF1PTGESKDM4E | |
| SCHEMBL5793120 | 0.73 | PTGES (0.36) | BRAFKDRRAF1TEKPTGES | |
| SCHEMBL5766766 | 0.72 | BRAF (0.53) | BRAFKDRRAF1TEK | |
| SCHEMBL5450821 | 0.72 | KDR (0.41) | BRAFKDRRAF1 | |
| SCHEMBL5807345 | 0.71 | RAF1 (0.42) | BRAFKDRRAF1TEK | |
| SCHEMBL14521447 | 0.70 | POLB (0.41) | KDRKDM4EMAPT | |
| SCHEMBL5450095 | 0.70 | KDR (0.44) | BRAFKDRRAF1TEKPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656377-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 2006-05-17 | — | — | EP | claimed |
| WO-2005019216-A1 | AMINOBENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-03-03 | — | — | WO | claimed |