Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | GNRHR | P30968 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 3/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5792823 | 0.91 | RXRA (0.43) | RXRANR1H2NR1H3ALDH1A1GNRHR | |
| SCHEMBL5793441 | 0.90 | RXRA (0.42) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL5793671 | 0.86 | RXRA (0.61) | RXRANR1H2NR1H3ALDH1A1GNRHR | |
| SCHEMBL5806479 | 0.85 | RXRA (0.45) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2263811 | 0.83 | NR1H2 (0.59) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL5615711 | 0.83 | RXRA (0.44) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL4897584 | 0.82 | NR1H2 (0.45) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL4906328 | 0.81 | NR1H2 (0.46) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL2264167 | 0.81 | NR1H2 (0.51) | RXRANR1H2NR1H3ALDH1A1KDM4E | |
| SCHEMBL5615714 | 0.80 | RXRA (0.43) | RXRANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |