Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4708291 | 0.83 | HPGD (0.39) | KCNH2HPGDALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL4706152 | 0.79 | RXFP1 (0.47) | KCNH2ALDH1A1CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL4638825 | 0.76 | HPGD (0.50) | HPGDGALR3CYP3A4CYP2C9NR2F2 | |
| SCHEMBL2367657 | 0.74 | GRN (0.49) | HPGDGALR3CYP3A4CYP2C9NR2F2 | |
| SCHEMBL4708213 | 0.72 | USP2 (0.44) | ALDH1A1CYP3A4CYP2C9SMN1; SMN2HIF1A | |
| SCHEMBL5797687 | 0.71 | CASP1 (0.43) | HPGDALDH1A1CYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL5795924 | 0.71 | CASP1 (0.42) | HPGDALDH1A1CYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL4708746 | 0.69 | TACR1 (0.42) | HPGDALDH1A1CYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL5793962 | 0.69 | CYP2D6 (0.39) | HPGDALDH1A1CYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL5769350 | 0.69 | CYP2D6 (0.44) | HPGDALDH1A1CYP3A4CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160794-A1 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY | 2006-07-20 | — | — | US | disclosed |
| EP-1638944-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000821-A1 | TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160794-A1 | Tachykinin receptor antagonists | TACR1, TACR2, PROKR1 | KCNH2 66/4885HPGD 1291/4885ALDH1A1 1815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.