SCHEMBL5797012

SCHEMBL5797012

[CH2]CSCc1ccccn1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.56
ALDH1A1 P00352 1/20 0.56
TSHR P16473 1/20 0.56
SMN1; SMN2 Q16637 3/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
MAPK1 P28482 1/20 0.49
LMNA P02545 1/20 0.49
KDM4E B2RXH2 2/20 0.47
MAPT P10636 2/20 0.47
HRH1 P35367 1/20 0.45
LIN28A Q9H9Z2 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP2E1 P05181 1/20 0.42
CYP2C8 P10632 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2B6 P20813 1/20 0.42
CYP2C19 P33261 1/20 0.42
DAO P14920 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6130015 0.87 CYP1A2 (0.63) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL8409739 0.84 ALDH1A1 (0.53) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL31058796 0.83 ALDH1A1 (0.59) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL8413014 0.81 ALDH1A1 (0.50) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL12055882 0.81 ALDH1A1 (0.58) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL30732408 0.81 ALDH1A1 (0.58) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL8411528 0.80 HRH1 (0.52) CYP1A2ALDH1A1NPC1RAB9AMAPK1
SCHEMBL11329150 0.79 ALDH1A1 (0.61) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL8793202 0.79 CYP1A2 (0.51) CYP1A2ALDH1A1TSHRSMN1; SMN2NPC1
SCHEMBL3983024 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997006153-A1 4-ALKYL-1,3-OXA(THIA)ZOLINE DERIVATIVES, THEIR PREPARATION AND USE FOR CONTROLLING ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 1997-02-20 WO claimed
WO-2006044133-A1 ACTIVE KETONE INHIBITORS OF TRYPTASE AXYS PHARMACEUTICALS, INC. (US) 2006-04-27 WO disclosed
US-5859030-A Substituted arylalkylthioalkylthiopyridines for use in the control of helicobacter bacteria BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1999-01-12 US disclosed
EP-0764161-A1 SUBSTITUTED ARYLALKYLTHIOALKYLTHIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1997-03-26 EP disclosed
WO-1997006153-A1 4-ALKYL-1,3-OXA(THIA)ZOLINE DERIVATIVES, THEIR PREPARATION AND USE FOR CONTROLLING ANIMAL PESTS BAYER AKTIENGESELLSCHAFT (DE) 1997-02-20 WO disclosed
WO-1996000224-A1 4-S- AND N-SUBSTITUTED 6-ALKYLPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-01-04 WO disclosed
WO-1995034554-A1 SUBSTITUTED ARYLALKYLTHIOALKYLTHIOPYRIDINES FOR USE IN THE CONTROL OF HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1995-12-21 WO disclosed