Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.77 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 9/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.53 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797447 | 0.94 | PTGER4 (0.71) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5737965 | 0.93 | PTGER4 (0.70) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5669392 | 0.93 | PTGER4 (0.71) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5654479 | 0.90 | PTGER4 (0.65) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5653855 | 0.90 | PTGER4 (0.65) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5651837 | 0.90 | PTGER4 (0.68) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5654843 | 0.90 | PTGER4 (0.77) | PTGER4NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL5654913 | 0.89 | PTGER4 (0.67) | PTGER4SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL5653780 | 0.89 | PTGER4 (0.82) | PTGER4NPC1RAB9A | |
| SCHEMBL5654978 | 0.89 | PTGER4 (0.65) | PTGER4SIRT5SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697337-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN-E2-AGONISTS OR ANTAGONISTS | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061475-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |