Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797554 | 0.88 | P2RX3 (0.47) | P2RX3CYP2D6MEN1KMT2AMETAP2 | |
| SCHEMBL5797676 | 0.82 | HDAC6 (0.42) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL1308741 | 0.80 | P2RX3 (0.73) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL1308738 | 0.80 | P2RX3 (0.73) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL1308735 | 0.80 | P2RX3 (0.73) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5797675 | 0.79 | HDAC6 (0.42) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5799447 | 0.79 | HDAC6 (0.43) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5797642 | 0.79 | HDAC6 (0.44) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5799320 | 0.77 | HDAC1 (0.40) | P2RX3HDAC1HDAC6HDAC8HDAC3 | |
| SCHEMBL5796847 | 0.77 | HDAC6 (0.40) | P2RX3HDAC1HDAC6HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006025683-A1 | ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-09 | — | — | WO | claimed |
| WO-2006025683-A1 | ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-09 | — | — | WO | disclosed |