Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5794626 | 0.79 | MAPT (0.44) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL4728729 | 0.76 | PTGER4 (0.69) | MAPTKDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL541427 | 0.73 | MAPT (0.57) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL17434605 | 0.72 | KMT2A (0.55) | TP53KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9459043 | 0.71 | PTGER4 (0.55) | MAPTTP53KDM4EALDH1A1RAB9A | |
| SCHEMBL23148486 | 0.70 | KDM4E (0.57) | MAPTKDM4EALDH1A1RAB9ALMNA | |
| SCHEMBL5795304 | 0.70 | ABCG2 (0.53) | MAPTKDM4EALDH1A1RAB9AHPGD | |
| SCHEMBL599985 | 0.70 | CNR2 (0.71) | KDM4E | |
| SCHEMBL15107555 | 0.69 | ALDH1A1 (0.51) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL6756508 | 0.68 | SCARB1 (0.63) | KDM4EALDH1A1HPGDPTGER4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006012310-A2 | CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE | GENZYME CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |