Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593090 | 0.89 | MAPK14 (0.49) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL5799690 | 0.87 | MAPK14 (0.57) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL5890443 | 0.85 | POLB (0.46) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL5800758 | 0.85 | MAPK9 (0.39) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL5210526 | 0.85 | TGFBR1 (0.50) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL12997420 | 0.85 | GSK3B (0.50) | GSK3BMAPK14ADORA3ADORA2AADORA1 | |
| SCHEMBL12997419 | 0.83 | GSK3B (0.58) | GSK3BMAPK14ADORA3ADORA2AADORA1 | |
| SCHEMBL5208955 | 0.82 | MAPK14 (0.45) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 | |
| SCHEMBL14627004 | 0.80 | MAPK14 (0.54) | GSK3BMAPK14ADORA3ADORA2AADORA1 | |
| SCHEMBL13848066 | 0.79 | TGFBR1 (0.42) | GSK3BTGFBR1TGFBR2MAPK14ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006055245-A2 | PROCESS FOR PREPARING PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-26 | — | — | WO | disclosed |