Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.57 |
| ▸ | GSK3B | P49841 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593090 | 0.91 | MAPK14 (0.49) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL14627004 | 0.88 | MAPK14 (0.54) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5208955 | 0.88 | MAPK14 (0.45) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5210526 | 0.87 | TGFBR1 (0.50) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5798463 | 0.87 | GSK3B (0.48) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5384464 | 0.83 | MAPK14 (0.60) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5800758 | 0.81 | MAPK9 (0.39) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5385825 | 0.81 | MAPK14 (0.60) | MAPK14GSK3BCSNK1ECCNA2CDK2 | |
| SCHEMBL13848066 | 0.81 | TGFBR1 (0.42) | MAPK14GSK3BEGFRRAF1ADORA3 | |
| SCHEMBL5383803 | 0.81 | MAPK14 (0.58) | MAPK14GSK3BEGFRRAF1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166597-B2 | Fused pyrazole derivatives being protein kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-01-23 | — | — | US | disclosed |
| US-7166597-B2 | Fused pyrazole derivatives being protein kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2007-01-23 | — | — | US | disclosed |
| WO-2006055245-A2 | PROCESS FOR PREPARING PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-26 | — | — | WO | disclosed |