Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Fosphenytoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.52 |
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.52 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.52 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.52 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosphenytoin SCHEMBL20769774 | 0.91 | POLB (0.56) | HRH1POLBTDP1NPC1MEN1 | |
| Fosphenytoin SCHEMBL94254 | 0.91 | POLB (0.56) | HRH1POLBTDP1NPC1MEN1 | |
| Fosphenytoin SCHEMBL1560790 | 0.90 | POLB (0.55) | HRH1POLBTDP1NPC1MEN1 | |
| Fosphenytoin SCHEMBL318673 | 0.90 | POLB (0.55) | HRH1POLBTDP1NPC1MEN1 | |
| Fosphenytoin SCHEMBL7205444 | 0.90 | POLB (0.55) | HRH1POLBTDP1NPC1MEN1 | |
| SCHEMBL2615240 | 0.84 | POLB (0.49) | POLBTDP1NPC1MEN1KMT2A | |
| Fosphenytoin SCHEMBL28132875 | 0.84 | POLB (0.49) | HRH1POLBTDP1NPC1MEN1 | |
| SCHEMBL18775360 | 0.81 | POLB (0.51) | HRH1POLBTDP1NPC1MEN1 | |
| SCHEMBL1725500 | 0.81 | POLB (0.55) | HRH1POLBTDP1NPC1MEN1 | |
| SCHEMBL8056128 | 0.80 | POLB (0.55) | HRH1POLBTDP1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027202-A1 | DRUG DELIVERY METHOD | Regents of the University of Minnesota (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017715-A1 | DRUG DELIVERY METHOD | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-02-05 | — | — | WO | disclosed |
| WO-2006060736-A2 | A COMPOSITION AND USE THEREOF IN ENHANCING A THERAPEUTIC EFFECT OF AN ANTIEPILEPTIC DRUG | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2006-06-08 | — | — | WO | disclosed |