Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798789 | 1.00 | ALDH1A1 (0.37) | ALDH1A1GLO1MAPTLMNANPSR1 | |
| SCHEMBL703137 | 0.88 | ALDH1A1 (0.36) | ALDH1A1MAPTLMNANPSR1HPGD | |
| SCHEMBL13990786 | 0.80 | ALDH1A1 (0.36) | ALDH1A1GLO1 | |
| SCHEMBL10743738 | 0.77 | GLO1 (0.64) | ALDH1A1GLO1MAPTLMNANPSR1 | |
| SCHEMBL4010131 | 0.77 | SMN1; SMN2 (0.30) | MAPTNPSR1 | |
| SCHEMBL9654192 | 0.76 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL666919 | 0.76 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL9397762 | 0.75 | ALDH1A1 (0.43) | ALDH1A1GLO1MAPTLMNANPSR1 | |
| SCHEMBL11551158 | 0.75 | ALDH1A1 (0.43) | ALDH1A1GLO1MAPTLMNANPSR1 | |
| SCHEMBL4903561 | 0.75 | ALDH1A1 (0.43) | ALDH1A1GLO1MAPTLMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066070-A2 | PRODRUG CONSTRUCTS OF PYRIMIDINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2006-06-22 | — | — | WO | disclosed |