Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL580592 | 0.85 | OPRM1 (0.56) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579758 | 0.84 | OPRM1 (0.58) | HTTALDH1A1LMNACYP1A2GLA | |
| SCHEMBL580074 | 0.79 | OPRM1 (0.51) | ALDH1A1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL580457 | 0.77 | OPRM1 (0.58) | ALDH1A1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL579849 | 0.77 | OPRM1 (0.53) | ALDH1A1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL580054 | 0.76 | OPRM1 (0.55) | HTTALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL579606 | 0.76 | OPRM1 (0.65) | ALDH1A1OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL579469 | 0.74 | OPRM1 (0.67) | SMN1; SMN2OPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL579444 | 0.74 | OPRM1 (0.60) | MAPTSMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL580267 | 0.74 | OPRM1 (0.50) | ALDH1A1SMN1; SMN2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735268-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-02-15 | — | — | EP | claimed |