Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ACP1 | P24666 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 1/20 | 0.41 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800044 | 0.91 | CYP19A1 (0.49) | CYP19A1MAPTTDP1SMN1; SMN2ACP1 | |
| SCHEMBL5799395 | 0.86 | ACP1 (0.55) | CYP19A1MAPTACP1KDM4EL3MBTL1 | |
| SCHEMBL5798960 | 0.86 | CYP19A1 (0.46) | CYP19A1MAPTSMN1; SMN2ACP1KDM4E | |
| SCHEMBL5799363 | 0.85 | PTGS2 (0.49) | CYP19A1TP53MAPK1HTTNPSR1 | |
| SCHEMBL6001417 | 0.82 | CYP19A1 (0.42) | CYP19A1MAPTSMN1; SMN2ACP1KDM4E | |
| SCHEMBL5815389 | 0.82 | TP53 (0.52) | MAPTTDP1TP53SMN1; SMN2KDM4E | |
| SCHEMBL5999861 | 0.80 | KDM4E (0.43) | CYP19A1MAPTTDP1TP53SMN1; SMN2 | |
| SCHEMBL5999868 | 0.79 | NR1H2 (0.44) | TP53ACP1MAPK1HTTNPSR1 | |
| SCHEMBL5802745 | 0.79 | ADRB2 (0.43) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL6001163 | 0.77 | GBA1 (0.47) | MAPTACP1KDM4EALDH1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | REDDY US THERAPEUTICS, INC. | 2006-06-15 | — | — | US | claimed |
| WO-2006058201-A2 | HETEROCYCLIC AND BICYCLIC COMPOUNDS, COMPOSITIONS AND METHODS | REDDY US THERAPEUTICS, INC. (US) | 2006-06-01 | — | — | WO | claimed |
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | REDDY US THERAPEUTICS, INC. | 2006-06-15 | — | — | US | disclosed |
| WO-2006058201-A2 | HETEROCYCLIC AND BICYCLIC COMPOUNDS, COMPOSITIONS AND METHODS | REDDY US THERAPEUTICS, INC. (US) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128702-A1 | Heterocyclic and bicyclic compounds, compositions and methods | HPSE, ENGASE, UGCG | CYP19A1 863/4885MAPT 4070/4885TDP1 2808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.