Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 18/20 | 0.62 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5433478 | 1.00 | MCHR1 (0.62) | MCHR1MAPK6KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5943481 | 0.94 | MCHR1 (0.62) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5433454 | 0.91 | MCHR1 (0.60) | MCHR1 | |
| SCHEMBL5440300 | 0.85 | MCHR1 (0.64) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5434552 | 0.84 | MCHR1 (0.62) | MCHR1 | |
| SCHEMBL5442154 | 0.83 | KDM4E (0.47) | MCHR1MAPK6KDM4ELMNASMN1; SMN2 | |
| SCHEMBL2537498 | 0.79 | CHEK2 (0.56) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL2537496 | 0.79 | CHEK2 (0.56) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL12247545 | 0.78 | MCHR1 (0.53) | MCHR1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL5438260 | 0.78 | MCHR1 (0.70) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706384-A1 | THERAPEUTIC AGENTS I | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066132-A1 | THERAPEUTIC AGENTS I | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |