Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 15/20 | 0.49 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799276 | 1.00 | HDAC1 (0.49) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5798821 | 0.92 | MAPT (0.43) | HDAC1MEN1KMT2APARP14ALDH1A1 | |
| SCHEMBL5798873 | 0.92 | PARP14 (0.41) | HDAC1P2RX3MEN1KMT2APARP14 | |
| SCHEMBL5798816 | 0.92 | MAPT (0.43) | HDAC1MEN1KMT2APARP14ALDH1A1 | |
| SCHEMBL5795455 | 0.90 | HDAC1 (0.47) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5799824 | 0.90 | HDAC1 (0.47) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5795513 | 0.88 | P2RX3 (0.42) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5795517 | 0.88 | P2RX3 (0.42) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5799088 | 0.87 | P2RX3 (0.55) | HDAC1P2RX3HDAC6HDAC3HDAC8 | |
| SCHEMBL5813024 | 0.87 | P2RX3 (0.55) | HDAC1P2RX3HDAC6HDAC3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006025683-A1 | ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-09 | — | — | WO | claimed |
| WO-2006025683-A1 | ARYLAMINOMETHYL PROPENYL BENZHYDROXYAMID DERIVATIVES WITH INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND METHOD FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-03-09 | — | — | WO | disclosed |