Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 13/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.63 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798859 | 0.80 | FGFR1 (0.47) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5809579 | 0.73 | MAPK11 (0.49) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5811997 | 0.73 | MAPK11 (0.57) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5795756 | 0.72 | MAPK11 (0.61) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5799438 | 0.70 | MAPK11 (0.61) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL4237486 | 0.69 | MAPK11 (0.79) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL4248353 | 0.69 | MAPK11 (0.54) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL29593357 | 0.69 | MAPK11 (0.79) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL5798606 | 0.68 | MAPK13 (0.46) | MAPK11MAPK14MAPK13MAPK12FGFR1 | |
| SCHEMBL4236978 | 0.68 | MAPK11 (0.65) | MAPK11MAPK14MAPK13MAPK12FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |