Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245618 | 0.80 | RAB9A (0.51) | KMT2AKDM4ERAB9AMEN1NPC1 | |
| SCHEMBL5795729 | 0.78 | CTNNB1 (0.47) | KMT2AKDM4EMEN1LMNAHPGD | |
| SCHEMBL5797417 | 0.75 | PIM1 (0.46) | PIM1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL5798675 | 0.74 | CYP1A2 (0.43) | KMT2AKDM4EPOLBRAB9AMEN1 | |
| SCHEMBL4240902 | 0.73 | AKR1B1 (0.45) | KMT2ARAB9AMEN1NPC1HTR2A | |
| SCHEMBL6282334 | 0.71 | PIM1 (0.50) | PIM1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL5798754 | 0.70 | PIM1 (0.40) | PIM1KMT2AKDM4EPOLBRAB9A | |
| SCHEMBL4621038 | 0.70 | PIM1 (0.55) | PIM1KMT2AKDM4EPOLBMEN1 | |
| SCHEMBL8256684 | 0.70 | PIM1 (0.55) | PIM1KMT2AKDM4EPOLBMEN1 | |
| SCHEMBL29977610 | 0.69 | GSK3B (0.55) | PIM1KMT2AKDM4EPOLBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |