Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240705 | 0.87 | LMNA (0.47) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 | |
| SCHEMBL4239808 | 0.81 | MAPK11 (0.46) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 | |
| SCHEMBL5795810 | 0.76 | MAPK11 (0.37) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 | |
| SCHEMBL5798494 | 0.72 | MAPK11 (0.35) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 | |
| SCHEMBL5799397 | 0.70 | PIM1 (0.45) | PIM1MAPK14ALDH1A1LMNASRC | |
| SCHEMBL5797417 | 0.69 | PIM1 (0.46) | PIM1L3MBTL1SRCKDM4EPOLB | |
| SCHEMBL14972980 | 0.65 | MEN1 (0.61) | PIM1ALDH1A1LMNASMN1; SMN2TDP1 | |
| SCHEMBL4243698 | 0.65 | ALDH1A1 (0.39) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 | |
| SCHEMBL6282334 | 0.65 | PIM1 (0.50) | PIM1ALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL5798859 | 0.65 | FGFR1 (0.47) | MAPK11MAPK14MAPK13MAPK12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |