Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 10/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872654 | 0.82 | CTSS (0.47) | PKMSMN1; SMN2CTSSHTTPOLB | |
| SCHEMBL3873043 | 0.81 | PKM (0.47) | PKMSMN1; SMN2CTSSPOLBGFER | |
| SCHEMBL6801412 | 0.80 | HTT (0.56) | PKMSMN1; SMN2CTSSHTTCAPN1 | |
| SCHEMBL5360405 | 0.80 | CTSS (0.51) | PKMSMN1; SMN2CTSSHTTPOLB | |
| SCHEMBL4828725 | 0.80 | CTSS (0.60) | PKMSMN1; SMN2CTSSHTTPOLB | |
| SCHEMBL10267070 | 0.80 | CTSS (0.60) | PKMSMN1; SMN2CTSSHTTPOLB | |
| SCHEMBL4828731 | 0.80 | CTSS (0.60) | PKMSMN1; SMN2CTSSHTTPOLB | |
| SCHEMBL7030377 | 0.78 | POLB (0.68) | PKMSMN1; SMN2CTSSPOLBCAPN1 | |
| SCHEMBL7030374 | 0.78 | POLB (0.68) | PKMSMN1; SMN2CTSSPOLBCAPN1 | |
| SCHEMBL3871052 | 0.76 | CTSS (0.50) | PKMSMN1; SMN2CTSSHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | disclosed |