Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | CDK2AP1 | O14519 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223869 | 0.86 | CHEK1 (0.53) | CHEK1HPGDSHTR4POLBKDM4E | |
| SCHEMBL4210074 | 0.82 | CHEK1 (0.54) | CHEK1POLBKDM4ECDK2AP1 | |
| SCHEMBL4209769 | 0.77 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL5784504 | 0.77 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4706363 | 0.76 | KDM4E (0.46) | CHEK1HPGDSHTR4POLBKDM4E | |
| Hydrochloric Acid SCHEMBL4221917 | 0.76 | CHEK1 (0.55) | CHEK1CDK2AP1 | |
| SCHEMBL4703508 | 0.75 | KDM4E (0.46) | CHEK1HPGDSPOLBKDM4ECDK2AP1 | |
| SCHEMBL4218235 | 0.74 | CHEK1 (0.73) | CHEK1KDM4ERAB9ACDK2AP1SMN1; SMN2 | |
| SCHEMBL4206722 | 0.74 | CHEK1 (0.76) | CHEK1CDK2AP1 | |
| SCHEMBL5801245 | 0.74 | CHEK1 (0.60) | CHEK1HTR4CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005016909-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-02-24 | — | — | WO | disclosed |