Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850885 | 0.82 | MEN1 (0.47) | POLBMEN1KMT2APARP1SIGMAR1 | |
| SCHEMBL3715656 | 0.80 | PARP1 (0.41) | POLBMEN1KMT2ACYP1A2PARP1 | |
| SCHEMBL28268711 | 0.79 | KDM4E (0.50) | MEN1KMT2AKDM4EL3MBTL1CYP3A4 | |
| SCHEMBL13504652 | 0.77 | KDM4E (0.37) | POLBPARP1KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL457470 | 0.76 | KDM4E (0.40) | MEN1KMT2ALMNAKDM4EL3MBTL1 | |
| SCHEMBL11763098 | 0.76 | KDM4E (0.36) | MEN1KMT2ALMNAKDM4EL3MBTL1 | |
| SCHEMBL15341175 | 0.76 | KDM4E (0.36) | MEN1KMT2ALMNAKDM4EL3MBTL1 | |
| SCHEMBL14604836 | 0.75 | KDM4E (0.44) | POLBLMNAPARP1KDM4EL3MBTL1 | |
| SCHEMBL580709 | 0.74 | GABRA1 (0.52) | PARP1KDM4EPLA2G2AALDH1A1 | |
| SCHEMBL457973 | 0.74 | KDM4E (0.35) | MEN1KMT2ALMNAKDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417125-B1 | N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-09-09 | — | — | EP | claimed |
| US-8772280-B2 | N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-07-08 | — | — | US | claimed |
| EP-2417125-A1 | N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-02-15 | — | — | EP | claimed |
| WO-2010108921-A1 | N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-09-30 | — | — | WO | claimed |
| EP-2417125-B1 | N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-09-09 | — | — | EP | disclosed |
| US-8772280-B2 | N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as MPS1 kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-07-08 | — | — | US | disclosed |
| WO-2010108921-A1 | N-ARYL-2-(2-ARYLAMINOPYRIMIDIN-4-YL)PYRROL-4-CARBOXAMIDE DERIVATIVES AS MPS1 KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-09-30 | — | — | WO | disclosed |
| CN-100497294-C | Aromatic diamine derivative, its preparation method and liquid crystal display component alignment film material containing it | CHANGXING CHEMICAL INDUSTRY CO (CN) | 2009-06-10 | — | — | CN | disclosed |
| CN-1495156-A | Aromatic diamine derivative, its preparation method and liquid crystal display component alignment film material containing it | 长兴化学工业股份有限公司 | 2004-05-12 | — | — | CN | disclosed |
| CN-1483722-A | Aromatic diamine derivative, its preparation method and liquid crystal display component alignment film material containing same | 长兴化学工业股份有限公司 | 2004-03-24 | — | — | CN | disclosed |