Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3277833 | 0.88 | PTGS1 (0.74) | PTGS2CYP2C9PTGS1PDPK1 | |
| SCHEMBL6175728 | 0.86 | PTGS1 (0.58) | PTGS2CYP2C9PTGS1PDPK1 | |
| SCHEMBL5780130 | 0.84 | PTGS2 (0.67) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL5344449 | 0.84 | PTGS1 (0.80) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL8266070 | 0.82 | PTGS2 (0.80) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL5426104 | 0.82 | PTGS2 (0.63) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL6094805 | 0.81 | MAPT (0.45) | PTGS2CYP2C9PTGS1TSHR | |
| SCHEMBL4587742 | 0.80 | PTGS2 (0.60) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL14198881 | 0.79 | PTGS1 (0.80) | PTGS2CYP2C9PTGS1PDPK1ALOX5 | |
| SCHEMBL4587038 | 0.79 | PTGS2 (0.63) | PTGS2CYP2C9PTGS1PDPK1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675585-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005037271-A2 | LARGE CONDUCTANCE CALCIUM-ACTIVATED K CHANNEL OPENER | TANABE SEIYAKU CO., LTD. (JP) | 2005-04-28 | — | — | WO | disclosed |