Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 15/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801076 | 0.90 | PDE5A (0.57) | PRKCIPRKCZSMN1; SMN2HTTMEN1 | |
| SCHEMBL5802431 | 0.86 | PRKCI (0.47) | PRKCIPRKCZSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5802365 | 0.83 | MEN1 (0.54) | PRKCISMN1; SMN2HTTMEN1MAPT | |
| SCHEMBL5781941 | 0.83 | PRKCI (0.74) | PRKCIPRKCZ | |
| SCHEMBL5777737 | 0.82 | METAP1 (0.54) | PRKCIPRKCZSMN1; SMN2HTTMEN1 | |
| SCHEMBL7519213 | 0.81 | PRKCI (0.44) | PRKCIPRKCZSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5782225 | 0.81 | KDM4E (0.63) | PRKCIPRKCZSMN1; SMN2MEN1MAPT | |
| SCHEMBL5119781 | 0.80 | PRKCI (0.48) | PRKCISMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL13164900 | 0.79 | SMN1; SMN2 (0.73) | PRKCISMN1; SMN2HTTMEN1MAPT | |
| SCHEMBL5799122 | 0.79 | MAPT (0.48) | PRKCISMN1; SMN2HTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |