Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CASR | P41180 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694088 | 0.83 | KCNH2 (0.39) | KCNH2BIRC5ALDH1A1TSHRCYP19A1 | |
| SCHEMBL408242 | 0.81 | BIRC5 (0.38) | BIRC5L3MBTL1NOTUM | |
| SCHEMBL5591817 | 0.76 | GSK3A (0.38) | CYP19A1TRPV1MPIPHOSPHO1SCN9A | |
| SCHEMBL28220764 | 0.73 | BIRC5 (0.62) | KIF11TDP1KCNH2BIRC5ALDH1A1 | |
| SCHEMBL145051 | 0.68 | KCNH2 (0.43) | TDP1KCNH2BIRC5CYP19A1MGLL | |
| SCHEMBL16462295 | 0.68 | TRPV1 (0.48) | KIF11BIRC5ALDH1A1TRPV1MPI | |
| SCHEMBL1450364 | 0.64 | NQO2 (0.47) | ALDH1A1MAPT | |
| SCHEMBL10971445 | 0.64 | — | — | |
| SCHEMBL5543369 | 0.63 | ALDH1A1 (0.38) | KIF11TDP1ALDH1A1TSHRTRPV1 | |
| SCHEMBL2541502 | 0.63 | BACE1 (0.37) | KIF11ALDH1A1TSHRMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670794-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | Amgen Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005033105-A2 | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2005-04-14 | — | — | WO | disclosed |