Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.60 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16949893 | 0.75 | ADORA2A (0.37) | ADORA1ADORA2AYTHDC1ADORA2BPI4KA | |
| SCHEMBL106573 | 0.75 | ADORA2A (1.00) | ADORA1ADORA2AYTHDC1CDK1ADORA2B | |
| SCHEMBL18721931 | 0.75 | ADORA1 (0.60) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 | |
| SCHEMBL130453 | 0.75 | ADORA1 (0.60) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 | |
| SCHEMBL30572667 | 0.75 | ADORA1 (0.60) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 | |
| SCHEMBL7147821 | 0.73 | ADORA2A (0.96) | ADORA1ADORA2AYTHDC1CDK1ADORA2B | |
| SCHEMBL7140260 | 0.73 | ADORA2A (0.96) | ADORA1ADORA2AYTHDC1CDK1ADORA2B | |
| SCHEMBL4379836 | 0.73 | CDK1 (0.44) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 | |
| SCHEMBL4379586 | 0.72 | ADORA1 (0.56) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 | |
| SCHEMBL12843997 | 0.72 | ADORA1 (0.56) | ADORA1ADORA2AYTHDC1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006058338-A2 | 4 - PIPERIDINECARBOXAMIDE DERIVATIVES AS MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | WO | disclosed |
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060116368-A1 | 4-Piperidinecarboxamide modulators of vanilloid VR1 receptor | VDAC1, TRPV1, HVCN1 | ADORA1 192/4885ADORA2A 469/4885YTHDC1 3666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.