Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30673980 | 0.82 | CHEK2 (0.35) | TRPA1PTGS1CACNA1C | |
| SCHEMBL21624997 | 0.82 | CHEK2 (0.35) | TRPA1PTGS1CACNA1C | |
| SCHEMBL7251725 | 0.76 | SMN1; SMN2 (0.38) | LMNA | |
| SCHEMBL10550330 | 0.75 | LMNA (0.31) | LMNATRPA1 | |
| SCHEMBL2104149 | 0.75 | HTR2C (0.39) | LMNA | |
| SCHEMBL3753050 | 0.75 | PTGS1 (0.47) | PTGS1 | |
| SCHEMBL2104696 | 0.74 | CYP19A1 (0.37) | — | |
| SCHEMBL13256930 | 0.74 | CYP3A4 (0.35) | — | |
| SCHEMBL2336888 | 0.73 | LMNA (0.46) | LMNATRPA1PTGS1CACNA1C | |
| SCHEMBL29352459 | 0.73 | LMNA (0.46) | LMNATRPA1PTGS1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663207-A2 | NOVEL METHODS FOR IDENTIFYING IMPROVED, NON-SEDATING a-2 AGON ISTS | Allergan, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005034849-A2 | METHODS FOR IDENTIFYING IMPROVED, NON-SEDATING ALPHA-2 AGONISTS | ALLERGAN, INC. (US) | 2005-04-21 | — | — | WO | disclosed |