Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | MAOB | P27338 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802633 | 0.85 | CCR2 (0.69) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL7758381 | 0.80 | MEN1 (0.75) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5779906 | 0.78 | CCR2 (0.69) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL14364237 | 0.75 | CCR2 (0.64) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6180574 | 0.73 | CCR2 (0.68) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5493182 | 0.73 | CCR2 (0.68) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL1429912 | 0.72 | NPC1 (0.46) | NPC1MEN1KMT2ARAB9APOLB | |
| SCHEMBL5491086 | 0.72 | CCR2 (0.67) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5493355 | 0.72 | CCR2 (0.63) | CCR2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5489348 | 0.71 | CCR2 (0.69) | CCR2NPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383757-B1 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK INC (US) | 2006-09-27 | — | — | EP | claimed |