Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802844 | 0.85 | CCR2 (0.68) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5783317 | 0.79 | CCR2 (0.70) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5489790 | 0.72 | CCR2 (0.64) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5495759 | 0.72 | CCR2 (0.61) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5782958 | 0.71 | RAB9A (0.85) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5487573 | 0.71 | KMT2A (0.72) | CCR2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL6180069 | 0.70 | CCR2 (0.64) | CCR2RAB9ANPC1MAOBMAPT | |
| SCHEMBL5780599 | 0.70 | RAB9A (0.75) | CCR2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL18157490 | 0.69 | KDM4E (0.50) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL1429912 | 0.69 | NPC1 (0.46) | RAB9ANPC1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383757-B1 | ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF | TELIK INC (US) | 2006-09-27 | — | — | EP | claimed |