Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10064192 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL5878419 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL27748790 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL17672623 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL1438742 | 0.80 | SMN1; SMN2 (0.71) | SMN1; SMN2L3MBTL1ALDH1A1GAAKDM4E | |
| SCHEMBL14401632 | 0.79 | HRH3 (0.70) | HRH3L3MBTL1ALDH1A1GAAKDM4E | |
| SCHEMBL4427286 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL3966761 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL4427282 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2HRH3L3MBTL1ALDH1A1GAA | |
| SCHEMBL7463625 | 0.78 | L3MBTL1 (0.47) | SMN1; SMN2HRH3L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720859-A2 | CHEMOKINE RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005077932-A2 | CHEMOKINE RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2005-08-25 | — | — | WO | disclosed |