Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 8/20 | 0.69 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.69 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.69 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.69 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.69 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.69 |
| ▸ | CCKBR | P32239 | 9/20 | 0.66 |
| ▸ | CCKAR | P32238 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13502675 | 0.91 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13869423 | 0.89 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5803561 | 0.88 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13502674 | 0.88 | PSEN1 (0.71) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7492908 | 0.84 | SCN9A (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2927644 | 0.82 | CCKBR (0.78) | CCKBRCCKAR | |
| SCHEMBL7207460 | 0.82 | CCKBR (0.78) | CCKBRCCKAR | |
| SCHEMBL6910028 | 0.80 | PSEN1 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6045062 | 0.80 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7213169 | 0.79 | CCKBR (0.85) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006071775-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | claimed |
| WO-2006071775-A2 | NOVEL COMPOUNDS USEFUL FOR BRADYKININ B1 RECEPTOR ANTAGONISM | ELAN PHARMACEUTICALS, INC. (US) | 2006-07-06 | — | — | WO | disclosed |