Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 15/20 | 0.85 |
| ▸ | CCKAR | P32238 | 9/20 | 0.85 |
| ▸ | GABRP | O00591 | 1/20 | 0.85 |
| ▸ | GABRD | O14764 | 1/20 | 0.85 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.85 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.85 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.85 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.85 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.85 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.85 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.85 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.85 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.85 |
| ▸ | GABRE | P78334 | 1/20 | 0.85 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.85 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.85 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.85 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524671 | 0.92 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL8977558 | 0.92 | CCKBR (0.81) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL8977570 | 0.92 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL9524675 | 0.92 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL8977565 | 0.92 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL8977555 | 0.92 | CCKBR (0.81) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL14180306 | 0.91 | CCKBR (0.74) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL9867540 | 0.90 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL9867693 | 0.90 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL9867550 | 0.90 | CCKBR (1.00) | CCKBRCCKARGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907644-A4 | PHARMACEUTICAL PREPARATION | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-0907644-A1 | PHARMACEUTICAL PREPARATION | Merck & Co., Inc. (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5817658-A | ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR | MERCK & COMPANY, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5776930-A | CARDIOVASCULAR DISORDERS | MERCK & COMPANY, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| WO-1998000405-A1 | PHARMACEUTICAL PREPARATION | MERCK & CO., INC. (US) | 1998-01-08 | — | — | WO | disclosed |
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5595990-A | TREATMENT OF CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5428031-A | Benzodiazepine analogs; cardiovascular disorders | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5426185-A | Antiarrhythmia agents having reduced side effects | MERCK & CO., INC. (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995014471-A1 | ANTIARRHYTHMIC BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |