Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807479 | 0.92 | MEN1 (0.53) | MEN1KMT2AMAPK1ATMDRD4 | |
| SCHEMBL5803650 | 0.91 | MEN1 (0.49) | MEN1KMT2AMAPK1DRD2CCR5 | |
| SCHEMBL5805494 | 0.82 | MEN1 (0.51) | MEN1KMT2AMAPK1ATMDRD4 | |
| SCHEMBL5899201 | 0.77 | MEN1 (0.63) | MEN1KMT2AMAPK1ATMDRD4 | |
| SCHEMBL5805757 | 0.74 | HTR1A (0.59) | DRD2 | |
| SCHEMBL5807466 | 0.74 | MAPK1 (0.62) | MEN1KMT2AMAPK1ATMDRD4 | |
| SCHEMBL5803228 | 0.72 | LMNA (0.49) | MEN1KMT2AMAPK1ACKR3 | |
| SCHEMBL5818308 | 0.70 | MEN1 (0.53) | MEN1KMT2AMAPK1ATMCHRM4 | |
| SCHEMBL5823977 | 0.70 | MEN1 (0.53) | MEN1KMT2AMAPK1ATMDRD4 | |
| SCHEMBL12024283 | 0.70 | MEN1 (0.58) | MEN1KMT2ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006088954-A1 | DIHYDROINDOLYL METHANONES AS ALPHA 1A/1D ADRENORECEPTOR MODULATORS FOR THE TREATMENT OF BENIGN PROSTATIC HYPERTROPHY AND LOWER URINARY TRACT SYMPTOMS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-08-24 | — | — | WO | disclosed |