Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.65 |
| ▸ | TNF | P01375 | 2/20 | 0.65 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | LTK | P29376 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368523 | 0.80 | MAPK1 (0.62) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL14669286 | 0.79 | FGFR1 (0.61) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL2369019 | 0.79 | MAPK1 (1.00) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL2369480 | 0.79 | LMNA (0.66) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL2369266 | 0.77 | MAPK1 (0.79) | MAPK1TNFNOD1FGFR1RXFP1 | |
| SCHEMBL4553755 | 0.74 | FGFR1 (0.67) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL5804191 | 0.72 | FGFR1 (0.56) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL6363985 | 0.72 | TNF (0.80) | MAPK1TNFNOD1FGFR1CSNK2A2 | |
| SCHEMBL2900101 | 0.72 | TNF (0.69) | MAPK1TNFNOD1FGFR1DAPK3 | |
| SCHEMBL16801668 | 0.71 | FGFR1 (0.67) | MAPK1TNFNOD1FGFR1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |