Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.66 |
| ▸ | CSNK2A2 | P19784 | 7/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 7/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.63 |
| ▸ | PRNP | P04156 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.61 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29620397 | 0.85 | L3MBTL1 (0.84) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL2368667 | 0.79 | L3MBTL1 (0.64) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL5804193 | 0.79 | MAPK1 (0.65) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL2368523 | 0.77 | MAPK1 (0.62) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL2369019 | 0.76 | MAPK1 (1.00) | LMNAMAPK1L3MBTL1CSNK2A2CSNK2B | |
| SCHEMBL2369266 | 0.74 | MAPK1 (0.79) | LMNAMAPK1L3MBTL1RXFP1TNF | |
| SCHEMBL5804191 | 0.72 | FGFR1 (0.56) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL2900101 | 0.69 | TNF (0.69) | LMNAMAPK1L3MBTL1CSNK2A2CSNK2A1 | |
| SCHEMBL2369475 | 0.68 | FGFR1 (0.67) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 | |
| SCHEMBL2368374 | 0.68 | SMN1; SMN2 (0.77) | LMNAMAPK1L3MBTL1GPR55CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| US-20050026935-A1 | Compounds | XENTION DISCOVERY LTD. | 2005-02-03 | — | — | US | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026935-A1 | Compounds | KCNJ11, KCNJ1, KCNH1 | LMNA 1126/4885MAPK1 667/4885L3MBTL1 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.