Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12106949 | 0.92 | MEN1 (0.47) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL2221231 | 0.87 | MEN1 (0.52) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL6225929 | 0.87 | GLA (0.46) | MEN1KMT2AEPHX2RXFP1ALDH1A1 | |
| SCHEMBL5802496 | 0.86 | MEN1 (0.51) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL16118624 | 0.82 | MEN1 (0.40) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL16259930 | 0.82 | MEN1 (0.52) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL13287421 | 0.81 | MEN1 (0.55) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL6058833 | 0.81 | RXFP1 (0.57) | MEN1KMT2ARXFP1ALDH1A1TSHR | |
| SCHEMBL136224 | 0.80 | KMT2A (0.73) | MEN1KMT2AMAPK1DPP9DPP8 | |
| SCHEMBL12104313 | 0.80 | MEN1 (0.48) | MEN1KMT2AMAPK1DPP9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763980-B1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H LUNDBECK AS (DK) | 2018-04-25 | — | — | EP | disclosed |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2016-11-10 | — | — | US | disclosed |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2016-11-10 | — | — | US | disclosed |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2016-11-10 | — | — | US | disclosed |
| US-9212165-B2 | Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same | H. LUNDBECK A/S (DK) | 2015-12-15 | — | — | US | disclosed |
| US-9212165-B2 | Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same | H. LUNDBECK A/S (DK) | 2015-12-15 | — | — | US | disclosed |
| US-9212165-B2 | Bicarbocyclic and tricarbocyclic ethynyl derivatives and uses of same | H. LUNDBECK A/S (DK) | 2015-12-15 | — | — | US | disclosed |
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2014-11-27 | — | — | US | disclosed |
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2014-11-27 | — | — | US | disclosed |
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2014-11-27 | — | — | US | disclosed |
| WO-2006090244-A1 | NEW ADAMANTANE DERIVATIVES AS DIPEPTIDYL, PEPTIDASE IV INHIBITORS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350030-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | CBR1, CYCS, CYP3A43 | MEN1 485/4885KMT2A 3162/4885MAPK1 4405/4885 |
| US-20160326154-A1 | BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME | CBR1, CYCS, CYP3A43 | MEN1 485/4885KMT2A 3162/4885MAPK1 4405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.