Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 16/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5790113 | 0.94 | LMNA (0.40) | MCHR1ROCK2ROCK1 | |
| SCHEMBL5762922 | 0.92 | MCHR1 (0.47) | MCHR1ROCK2 | |
| SCHEMBL5846949 | 0.84 | PDE10A (0.39) | MCHR1ROCK2 | |
| SCHEMBL5846345 | 0.82 | EGLN1 (0.39) | MCHR1ROCK2 | |
| SCHEMBL5760136 | 0.81 | ROCK2 (0.51) | MCHR1ROCK2 | |
| SCHEMBL5847025 | 0.81 | MCHR1 (0.48) | MCHR1ROCK2ROCK1 | |
| SCHEMBL5762721 | 0.81 | MCHR1 (0.48) | MCHR1ROCK2ROCK1 | |
| SCHEMBL5761129 | 0.80 | MCHR1 (0.45) | MCHR1 | |
| SCHEMBL5759920 | 0.79 | TRPV1 (0.42) | MCHR1ROCK2 | |
| SCHEMBL5763136 | 0.79 | MCHR1 (0.47) | MCHR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638932-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004110994-A1 | NOVEL PIPERAZINYL-ARYLOXY AND PIPERAZINYL-HETEROARYLOXY-N-ARYL LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |