⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1142734 | 0.86 | — | — | |
| SCHEMBL27388605 | 0.84 | ALDH1A1 (0.47) | — | |
| Urea SCHEMBL235649 | 0.79 | ALDH1A1 (0.50) | — | |
| SCHEMBL9242577 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL8316401 | 0.79 | TDP1 (0.37) | — | |
| SCHEMBL22856384 | 0.79 | EPHX1 (0.37) | — | |
| Formaldehyde SCHEMBL7061736 | 0.78 | TDP1 (0.33) | — | |
| Urea SCHEMBL11541326 | 0.78 | ALDH1A1 (0.33) | — | |
| SCHEMBL14526173 | 0.77 | — | — | |
| SCHEMBL5312005 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823420-B1 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO (JP) | 2001-10-24 | — | — | EP | claimed |
| US-5866609-A | PROPHYLACTIC AND THERAPEUTIC AGENTS FOR ARTERIOSCLEROSIS. | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-02-02 | — | — | US | claimed |
| EP-0823420-A2 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | claimed |
| WO-2023016488-A1 | MICROTUBULE INHIBITOR-BASED ANTIBODY-DRUG CONJUGATE | 昆山新蕴达生物科技有限公司 | 2023-02-16 | — | — | WO | disclosed |
| WO-2023278592-A1 | RADIOLABELED PARP INHIBITOR CONJUGATES FOR CANCER TREATMENT | DUKE UNIVERSITY (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2022115451-A1 | MCL-1 INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022115477-A1 | BCL-XL INHIBITOR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF | NOVARTIS AG (CH) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022078462-A1 | NOVEL GLUTAMINE ANALOGS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |
| US-11180533-B2 | Process for the preparation of Cetrorelix acetate | BIOPHORE INDIA PHARMACEUTICALS PRIVATE LIMITED (IN) | 2021-11-23 | — | — | US | disclosed |
| WO-2021209007-A1 | ANTIBODY-DRUG CONJUGATE | SHENZHEN ENDURING BIOTECH, LTD. (CN) | 2021-10-21 | — | — | WO | disclosed |
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |
| EP-2845866-B1 | Antibodies and immunoconjugates and uses therefor | GENENTECH INC (US) | 2017-05-03 | — | — | EP | disclosed |
| EP-2956173-B1 | TUBULYSIN COMPOUNDS, METHODS OF MAKING AND USE | BRISTOL MYERS SQUIBB CO (US) | 2017-03-29 | — | — | EP | disclosed |
| WO-2017009255-A1 | COMPOSITIONS COMPRISING ANTIBODY-DUOCARMYCIN DRUG CONJUGATES | SYNTHON BIOPHARMACEUTICALS B.V. (NL) | 2017-01-19 | — | — | WO | disclosed |
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| EP-0823420-B1 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5866609-A | PROPHYLACTIC AND THERAPEUTIC AGENTS FOR ARTERIOSCLEROSIS. | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0823420-A2 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |
| US-4260552-A | INSECTICIDES, HERBICIDES | UNIROYAL, INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4160846-A | Method for controlling insects with tetrasubstituted organotin compounds | UNIROYAL, INC. (US) | 1979-07-10 | — | — | US | disclosed |