Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 8/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 8/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 8/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 8/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 8/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | NAMPT | P43490 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804658 | 0.82 | HDAC1 (0.59) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5807471 | 0.80 | HDAC1 (0.52) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5804435 | 0.77 | MC5R (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5804438 | 0.75 | HDAC1 (0.49) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5807825 | 0.73 | TRPM8 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5806295 | 0.72 | HDAC3 (0.67) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5806291 | 0.72 | HDAC3 (0.67) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5808247 | 0.71 | HDAC1 (0.51) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5805627 | 0.71 | CDK4 (0.48) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL13949845 | 0.70 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |