Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 7/20 | 0.49 |
| ▸ | MC3R | P41968 | 7/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | MC4R | P32245 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804658 | 0.85 | HDAC1 (0.59) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5807471 | 0.85 | HDAC1 (0.52) | MC3RHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5805627 | 0.83 | CDK4 (0.48) | MC5RMC3RHDAC1HDAC3HDAC4 | |
| SCHEMBL5804438 | 0.82 | HDAC1 (0.49) | MC5RMC3RHDAC1HDAC3HDAC4 | |
| SCHEMBL5807879 | 0.79 | KMT2A (0.55) | MC5RMC3RMC4RKMT2ATAAR1 | |
| SCHEMBL5807825 | 0.79 | TRPM8 (0.53) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5804661 | 0.77 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5806021 | 0.75 | CDK4 (0.44) | MC5RMC3RHDAC1HDAC3HDAC4 | |
| SCHEMBL5808553 | 0.73 | CDK4 (0.53) | HTR1AADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL5804585 | 0.73 | HDAC1 (0.59) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |