Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7127675 | 0.81 | CYP1A2 (0.45) | ALDH1A1TSHRKDM4EGLA | |
| SCHEMBL30265074 | 0.76 | TSHR (0.58) | ALDH1A1SMN1; SMN2TSHRKDM4EPOLB | |
| SCHEMBL3736562 | 0.73 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL29672523 | 0.71 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL31086880 | 0.71 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL26921315 | 0.71 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL5222020 | 0.70 | SMN1; SMN2 (0.67) | ALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL5758424 | 0.70 | GABRR1 (0.40) | POLB | |
| SCHEMBL15648958 | 0.69 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TSHRKDM4EGLA | |
| SCHEMBL3082957 | 0.69 | SMN1; SMN2 (0.62) | ALDH1A1SMN1; SMN2TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255764-B8 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | claimed |
| JP-2004508284-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1255764-A1 | PURINE DERIVATIVES | PFIZER INC. (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060835-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-08-23 | — | — | WO | claimed |