Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRR1 | P24046 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.33 |
| ▸ | HTR3B | O95264 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7559521 | 0.79 | RAB9A (0.53) | KMT2AL3MBTL1 | |
| SCHEMBL4400656 | 0.74 | GABRR1 (0.53) | GABRR1HRH4HRH3HRH2HRH1 | |
| SCHEMBL7127675 | 0.73 | CYP1A2 (0.45) | KMT2AL3MBTL1 | |
| SCHEMBL7771667 | 0.71 | SLC2A1 (0.37) | TDP1KMT2A | |
| SCHEMBL7559021 | 0.70 | MERTK (0.37) | HTT | |
| SCHEMBL5804723 | 0.70 | ALDH1A1 (0.51) | POLB | |
| SCHEMBL14125935 | 0.70 | KDM4E (0.46) | KMT2APOLB | |
| SCHEMBL5349497 | 0.69 | HDAC6 (0.36) | TDP1KMT2APOLBHTT | |
| SCHEMBL31269349 | 0.69 | HSD17B10 (0.33) | GABRR1HTT | |
| SCHEMBL4436717 | 0.69 | HSD17B10 (0.33) | GABRR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255764-B8 | PURINE DERIVATIVES | PFIZER LTD (GB) | 2006-06-28 | — | — | EP | claimed |
| JP-2004508284-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1255764-A1 | PURINE DERIVATIVES | PFIZER INC. (US) | 2002-11-13 | — | — | EP | claimed |
| WO-2001060835-A1 | PURINE DERIVATIVES | PFIZER LIMITED (GB) | 2001-08-23 | — | — | WO | claimed |