Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 8/20 | 0.66 |
| ▸ | GSK3B | P49841 | 7/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | PIN1 | Q13526 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31465489 | 0.82 | PIN1 (0.48) | GSK3AGSK3BAURKAPIN1 | |
| SCHEMBL5806420 | 0.82 | GSK3A (0.65) | GSK3AGSK3BAURKANPC1RAB9A | |
| SCHEMBL5806156 | 0.80 | GSK3A (0.63) | GSK3AGSK3BAURKANPC1RAB9A | |
| SCHEMBL5806176 | 0.80 | GSK3A (0.63) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL5820019 | 0.80 | GSK3A (1.00) | GSK3AGSK3BAURKA | |
| SCHEMBL5806863 | 0.80 | GSK3A (1.00) | GSK3AGSK3BAURKA | |
| SCHEMBL23618787 | 0.80 | GSK3A (0.49) | GSK3AGSK3BAURKAADORA3ADORA1 | |
| SCHEMBL23618785 | 0.74 | GSK3A (0.44) | GSK3AGSK3BAURKANPC1RAB9A | |
| SCHEMBL17168791 | 0.71 | PIN1 (0.53) | GSK3AGSK3BPIN1MEN1MAPT | |
| SCHEMBL15218875 | 0.69 | PIN1 (0.39) | GSK3AGSK3BAURKAPIN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |