Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.46 |
| ▸ | ULK1 | O75385 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30861017 | 0.73 | ULK1 (0.49) | ULK1KMT2AULK2 | |
| SCHEMBL27227925 | 0.73 | ULK1 (0.49) | ULK1KMT2AULK2 | |
| SCHEMBL27227803 | 0.72 | ULK1 (0.44) | GABBR2GABBR1ULK1KMT2AULK2 | |
| SCHEMBL30860901 | 0.72 | ULK1 (0.44) | GABBR2GABBR1ULK1KMT2AULK2 | |
| SCHEMBL12985293 | 0.72 | GSK3A (0.41) | GSK3AGSK3BGABBR2GABBR1HDAC3 | |
| SCHEMBL1935005 | 0.72 | ULK1 (0.61) | ULK1KMT2AULK2 | |
| SCHEMBL19313030 | 0.72 | GABBR2 (0.40) | GSK3AGSK3BGABBR2GABBR1ULK1 | |
| SCHEMBL1935075 | 0.71 | ULK1 (0.43) | ULK1KMT2ACYP1A2LRRK2ULK2 | |
| SCHEMBL11915897 | 0.71 | GSK3A (0.48) | GSK3AGSK3BULK1ULK2 | |
| SCHEMBL11919347 | 0.71 | GSK3A (0.48) | GSK3AGSK3BULK1ULK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006091737-A1 | MODULATORS OF GSK-3 ACTIVITY | KEMIA, INC. (US) | 2006-08-31 | — | — | WO | disclosed |