Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787523 | 0.91 | TGFBR1 (0.69) | TGFBR1MAPK14KDRGABRA5ATR | |
| SCHEMBL5792548 | 0.88 | TGFBR1 (0.52) | TGFBR1MAPK14KDRGABRA5ATR | |
| SCHEMBL5787865 | 0.80 | BRD4 (0.46) | TGFBR1MAPK14KDRALDH1A1GAA | |
| SCHEMBL5789755 | 0.79 | MAPT (0.47) | TGFBR1ALDH1A1GAAMAPTMAPK1 | |
| SCHEMBL373524 | 0.78 | TGFBR1 (0.70) | TGFBR1MAPK14KDRGABRA5ATR | |
| SCHEMBL29358505 | 0.78 | TGFBR1 (0.70) | TGFBR1MAPK14KDRGABRA5ATR | |
| Water SCHEMBL29649721 | 0.77 | TGFBR1 (0.69) | TGFBR1MAPK14KDRGABRA5ATR | |
| Water SCHEMBL21633982 | 0.77 | TGFBR1 (0.69) | TGFBR1MAPK14KDRGABRA5ATR | |
| Water SCHEMBL29649719 | 0.77 | TGFBR1 (0.69) | TGFBR1MAPK14KDRGABRA5ATR | |
| SCHEMBL5790886 | 0.77 | USP7 (0.48) | TGFBR1ALDH1A1GAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | TGFBR1 4/4885MAPK14 285/4885KDR 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.