SMAD2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL10150389	0.43	9/20
SCHEMBL14293422	0.41	9/20
SCHEMBL19418072	0.39	9/20
SCHEMBL10150003	0.38	9/20
SCHEMBL10150861	0.37	9/20
SCHEMBL10150174	0.36	9/20
SCHEMBL19431868	0.36	9/20
SCHEMBL14292771	0.35	9/20
SCHEMBL20840829	0.35	9/20
SCHEMBL10186746	0.34	9/20
SCHEMBL19418327	0.34	9/20
SCHEMBL19418461	0.34	9/20
SCHEMBL10150008	0.34	9/20
SCHEMBL20840808	0.33	9/20
SCHEMBL19418317	0.36	8/20
SCHEMBL19418011	0.34	8/20
SCHEMBL20840851	0.33	8/20
SCHEMBL19418002	0.38	7/20
SCHEMBL19418436	0.37	7/20
SCHEMBL21370838	0.35	7/20

Clinical trials — most relevant to SMAD2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Roxadustat Combined With Luspatercept Versus Luspatercept Monotherapy in the Treatment of Refractory MDS-RS	PHASE4	UNKNOWN
Luspatercept vs Epoetin in Treating Poor Erythroid Engraftment for Hematological Malignancies	PHASE2/PHASE3	NOT_YET_RECRUITING
A Trial of Tadalafil in Interstitial Lung Disease of Scleroderma	PHASE3	COMPLETED
Luspatercept in Preventing Poor Erythroid Engraftment for Hematological Malignancies With Moderate to Severe Myelofibrosis	PHASE2/PHASE3	NOT_YET_RECRUITING
The Effect of Ramipril in Suppressing ST2 Expression in Rheumatic Mitral Stenosis Patients	PHASE3	UNKNOWN
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C	PHASE3	COMPLETED
Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial	PHASE1/PHASE2	COMPLETED
A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor	PHASE1/PHASE2	COMPLETED
The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect	PHASE1/PHASE2	COMPLETED
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)	PHASE2	COMPLETED
Efficacy and Safety of Oltipraz in the Patients With Liver Fibrosis and Cirrhosis	PHASE2	COMPLETED
First in Human Dose Escalation Study of Vactosertib (TEW-7197) in Subjects With Advanced Stage Solid Tumors	PHASE1	COMPLETED
Safety and Tolerability of AP 12009, Administered I.V. in Patients With Advanced Tumors Known to Overproduce TGF-beta-2	PHASE1	COMPLETED
Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis	nan	UNKNOWN
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Assessment of the TGF-beta Pathway and Micro-RNA in Pediatric Pulmonary Arterial Hypertension	nan	UNKNOWN
Clinical Application of 68Ga-1A12 PET in Fibrosis-related Diseases	nan	NOT_YET_RECRUITING
Role of Novel Biomarkers Associated With In-stent Restenosis After Percutaneous Coronary Intervention	nan	UNKNOWN
Role of Nox2 in CNI-induced Renal Fibrosis	nan	COMPLETED
Epithelial Mesenchymal Transition and Periodontitis	nan	UNKNOWN
Prevention and Early Detection Biomarkers of Adenomas and CRC Lesions During CRC Screening	nan	COMPLETED
The BRAVE Study- The Identification of Genetic Variants Associated With Bicuspid Aortic Valve Using a Combination of Case-control and Family-based Approaches.	nan	RECRUITING
Glucose Homeostasis and Shared Genetic Factors in Colorectal Cancer	nan	NOT_YET_RECRUITING
Genes Modulating the Severity of Aortic Aneurysms (MSF1-TGFBR2)	nan	UNKNOWN
Effect of BMPR-2 Gene Mutations on Hemodynamic Response by Iloprost Inhalation in Pulmonary Arterial Hypertension	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Vitamin D Deficiency and Effect of Its Supplementation on Interstitial Lung Diseases(ILD).	nan	UNKNOWN
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
Molecular Biology of Anal Cancer in HIV-Positive Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SMAD2 binder may also engage these)

Protein	Name	Similarity
Q62432	—	1.000	Q62432 →
Q5R7C0	—	1.000	Q5R7C0 →
Q9I9P9	—	1.000	Q9I9P9 →
Q1W668	—	1.000	Q1W668 →
O70436	—	1.000	O70436 →
P97588	—	1.000	P97588 →
O96660	—	1.000	O96660 →
Q9I8V2	—	1.000	Q9I8V2 →
P42003	—	1.000	P42003 →
P84024	—	1.000	P84024 →
O15198	—	0.999	O15198 →
Q9W7E7	—	0.999	Q9W7E7 →
SMAD3	Mothers against decapentaplegic homolog 3	0.999	landscape →
P84025	—	0.999	P84025 →
Q8BUN5	—	0.999	Q8BUN5 →
P11824	—	0.998	P11824 →
Q1JQA2	—	0.998	Q1JQA2 →
Q9BYI3	—	0.998	Q9BYI3 →
P84023	—	0.998	P84023 →
B9EJV3	—	0.998	B9EJV3 →
Q9I962	—	0.997	Q9I962 →
P11823	—	0.997	P11823 →
Q10095	—	0.997	Q10095 →
Q5VYS4	—	0.997	Q5VYS4 →
P11806	—	0.997	P11806 →
P16794	—	0.997	P16794 →
Q8MSX2	—	0.997	Q8MSX2 →
Q21733	—	0.997	Q21733 →
P06435	—	0.997	P06435 →
Q15797	—	0.996	Q15797 →