Desfesoterodine

Desfesoterodine

SCHEMBL580657

CC(C)N(CCC(c1ccccc1)c1cc(CO)ccc1O)C(C)C

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 12/20 0.72
CHRM2 P08172 3/20 0.72
CHRM1 P11229 3/20 0.72
CHRM5 P08912 2/20 0.72
HRH1 P35367 2/20 0.72
LMNA P02545 1/20 0.72
ESR1 P03372 1/20 0.72
CHRM4 P08173 1/20 0.72
MAPT P10636 1/20 0.72
KCNE1 P15382 1/20 0.72
PTGS1 P23219 1/20 0.72
HRH2 P25021 1/20 0.72
HTR2A P28223 1/20 0.72
SLC6A4 P31645 1/20 0.72
ADRA1A P35348 1/20 0.72
OPRK1 P41145 1/20 0.72
KCNQ1 P51787 1/20 0.72
KCNH2 Q12809 1/20 0.72
CACNA1C Q13936 1/20 0.72
SCN5A Q14524 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Desfesoterodine SCHEMBL816124 1.00 CHRM3 (0.72) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL29468683 1.00 CHRM3 (0.72) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL209062 1.00 CHRM3 (0.72) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL28757704 0.95 CHRM3 (0.66) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL1808420 0.94 CHRM2 (0.68) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL1811715 0.94 CHRM2 (0.68) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL1808422 0.94 CHRM2 (0.68) CHRM3CHRM2CHRM1CHRM5HRH1
Desfesoterodine SCHEMBL14696972 0.92 CHRM2 (0.62) CHRM3CHRM2CHRM1CHRM5HRH1
SCHEMBL27490008 0.91 CHRM3 (0.60) CHRM3CHRM2CHRM1CHRM5HRH1
SCHEMBL27491771 0.91 CHRM3 (0.60) CHRM3CHRM2CHRM1CHRM5HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 520 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3104848-B1 INHALABLE PARTICLE FORMULATIONS COMPRISING AN ANTIMUSCARINIC AGENT CRYSTEC LTD (GB) 2020-05-06 EP claimed
CN-106163505-B Improvements relating to inhalable particles 科瑞思特有限公司 2020-04-24 CN claimed
US-9085509-B2 Process for preparing fesoterodine ALEMBIC PHARMACEUTICALS LIMITED (IN) 2015-07-21 US claimed
US-9012678-B2 Processes for the preparation of fesoterodine CADILA HEALTHCARE LIMITED (IN) 2015-04-21 US claimed
EP-2686288-B1 A PROCESS FOR PREPARING FESOTERODINE ALEMBIC PHARMACEUTICALS LTD (IN) 2015-03-25 EP claimed
EP-2416761-B1 DESFESOTERODIN IN THE FORM OF A TARTARIC ACID SALT RATIOPHARM GMBH (DE) 2015-02-11 EP claimed
US-8946456-B2 Process for the preparation of 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol and (R)-feso-deacyl CHEMI S.P.A. (IT) 2015-02-03 US claimed
EP-2580203-B1 PROCESS FOR THE PREPARATION OF 2-HYDROXY-4-PHENYL-3,4-DIHYDRO-2H-CHROMEN-6-YL-METHANOL AND (R)-FESO-DEACYL CHEMI SPA (IT) 2014-08-13 EP claimed
EP-2027103-B1 NEW CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF UCB PHARMA GMBH (DE) 2014-02-26 EP claimed
US-20140039216-A1 PROCESS FOR PREPARING FESOTERODINE ALEMBIC PHARMACEUTICALS LIMITED (IN) 2014-02-06 US claimed
WO-2003002059-A2 TOLTERODINE METABOLITES BRIDGE PHARMA, INC. (US) 2003-01-09 WO claimed
EP-1254890-A1 Derivatives of 3,3-diphenylpropylamines SCHWARZ PHARMA AG (DE) 2002-11-06 EP claimed
EP-1077912-B1 NOVEL DERIVATIVES OF 3,3-DIPHENYLPROPYLAMINES SANOL ARZNEI SCHWARZ GMBH (DE) 2002-07-03 EP claimed
EP-1105111-A1 TRANSDERMALLY ADMINISTERED TOLTERODINE AS ANTI-MUSCARINIC AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER Pharmacia AB (SE) 2001-06-13 EP claimed
WO-2000012070-A1 TRANSDERMALLY ADMINISTERED TOLTERODINE AS ANTI-MUSCARINIC AGENT FOR THE TREATMENT OF OVERACTIVE BLADDER PHARMACIA & UPJOHN AB (SE) 2000-03-09 WO claimed
EP-0667852-B1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION PHARMACIA & UPJOHN AB (SE) 1998-04-08 EP claimed
US-5559269-A ANTICHOLINERGIC AGENTS PHARMACIA AB (SE) 1996-09-24 US claimed
EP-0667852-A1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION Pharmacia & Upjohn Aktiebolag (SE) 1995-08-23 EP claimed
WO-1994011337-A9 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION 1995-07-06 WO claimed
WO-1994011337-A1 NOVEL 3,3-DIPHENYLPROPYLAMINES, THEIR USE AND PREPARATION PHARMACIA AB (SE) 1994-05-26 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140039216-A1 PROCESS FOR PREPARING FESOTERODINE FES, QDPR, CYP4F3 CHRM3 220/4885CHRM2 417/4885CHRM1 940/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.