Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.75 |
| ▸ | CA12 | O43570 | 8/20 | 0.75 |
| ▸ | CA1 | P00915 | 7/20 | 0.75 |
| ▸ | CA9 | Q16790 | 6/20 | 0.75 |
| ▸ | CA7 | P43166 | 4/20 | 0.75 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.75 |
| ▸ | CA5A | P35218 | 2/20 | 0.75 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.75 |
| ▸ | CA4 | P22748 | 2/20 | 0.75 |
| ▸ | CA3 | P07451 | 1/20 | 0.75 |
| ▸ | CA6 | P23280 | 1/20 | 0.75 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.75 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Chlorobenzenesulfonamide SCHEMBL31527679 | 0.87 | CA2 (1.00) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL196556 | 0.87 | CA2 (1.00) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL11754428 | 0.84 | CA2 (0.95) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL30656204 | 0.84 | CA2 (0.95) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL8054986 | 0.84 | CA2 (0.95) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL28552470 | 0.84 | CA2 (0.95) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL27576052 | 0.84 | CA2 (0.95) | CA2CA12CA1CA9CA7 | |
| SCHEMBL8978672 | 0.83 | ALDH1A1 (0.73) | CA2CA12CA1CA9CA7 | |
| SCHEMBL9476326 | 0.83 | ALDH1A1 (0.73) | CA2CA12CA1CA9CA7 | |
| P-Chlorobenzenesulfonamide SCHEMBL29135710 | 0.82 | CA2 (0.90) | CA2CA12CA1CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |