Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | ACHE | P22303 | 4/20 | 0.65 |
| ▸ | CDK4 | P11802 | 5/20 | 0.64 |
| ▸ | CCND1 | P24385 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803804 | 0.89 | CDK4 (0.64) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5808542 | 0.86 | SIRT1 (0.69) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL26429907 | 0.83 | SIRT1 (0.73) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5807581 | 0.82 | MAPT (0.64) | MEN1KMT2APOLBMAPTSMN1; SMN2 | |
| SCHEMBL28906084 | 0.81 | NPC1 (0.78) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL4331421 | 0.81 | MEN1 (1.00) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23054820 | 0.80 | NPC1 (0.70) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL15047821 | 0.80 | MEN1 (0.82) | SIRT1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL5804384 | 0.79 | IGF1R (0.53) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL13942340 | 0.79 | MEN1 (0.81) | SIRT1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |