Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | GABRP | O00591 | 5/20 | 0.51 |
| ▸ | GABRD | O14764 | 5/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 5/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.51 |
| ▸ | GABRE | P78334 | 5/20 | 0.51 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.51 |
| ▸ | GABRG1 | Q8N1C3 | 5/20 | 0.51 |
| ▸ | GABRG3 | Q99928 | 5/20 | 0.51 |
| ▸ | GABRQ | Q9UN88 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807581 | 0.82 | MAPT (0.64) | MEN1POLBKMT2A | |
| SCHEMBL8251765 | 0.81 | GABRP (0.74) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5807408 | 0.79 | SIRT1 (0.67) | MEN1POLBKMT2ANPC1RAB9A | |
| SCHEMBL5805518 | 0.77 | IGF1R (0.46) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL5805515 | 0.77 | IGF1R (0.46) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL4923536 | 0.77 | HDAC6 (0.66) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18082339 | 0.76 | MAPT (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL8230790 | 0.75 | GABRP (0.54) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL12903051 | 0.74 | PBRM1 (0.60) | IGF1RGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13101464 | 0.74 | KMT2A (0.54) | MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |